UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties.
نویسندگان
چکیده
Novel antifungal antibiotics, UK-2A, B and a mixture of C and D, were obtained from the mycelial cake of Streptomyces sp. 517-02. All of the UK-2 compounds were similar in structure to antimycin A. The antifungal activities of UK-2 compounds were as strong as that of antimycin A. However, the UK-2 compounds demonstrated weak cytotoxicity compared to antimycin A.
منابع مشابه
UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. VI(1). Structure-activity relationships of UK-2A.
UK-2A, B, C and D (UK-2 compounds) were isolated from Streptomyces sp. 517-02, and are similar to antimycin A3 (AA) in their structure and inhibitory activities towards electron transport at complex III in mitochondria1-3). However, the benzyl group at the C2 position in UK-2A (main component of UK-2 compounds) has never been found in known antimycins and a methyl group is lacking at the C8 pos...
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UK-2A, a novel antifungal antibiotic, is a structural relative of antimycin A3 (AA) and its mode of action is similar to that of AA which inhibits mitochondrial electron transport at complex III. In spite of their structural resemblance, AA had strong cytotoxicity while UK-2A had little cytotoxicity against LLC-PK1 cells as well as other types of cultured cells. When cells were treated with UK-...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 49 7 شماره
صفحات -
تاریخ انتشار 1996